Living in a world that is valued only as gain, an ever-expanding world-as-frontier that has no worth of its own, no fullness of its own, you live in danger of losing your own worth to yourself. That's when you begin to listen to the voices from the other side, and to ask questions of failure and the dark.
Of course we're all programmed genetically to some extent. But the "selfish gene" thesis doesn't explain everything.