In the dog two conditions were found to produce pathological disturbances by functional interference, namely, an unusually acute … - Ivan Pavlov

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I thought that there were two rules in life - never count the cost, and never do anything unless you can do it wholeheartedly. Now is the time to live.

Ivan Pavlov

In the dog two conditions were found to produce pathological disturbances by functional interference, namely, an unusually acute clashing of the excitatory and inhibitory processes, and the influence of strong and extraordinary stimuli. In man precisely similar conditions constitute the usual causes of nervous and psychic disturbances. Different conditions productive of extreme excitation, such as intense grief or bitter insults, often lead, when the natural reactions are inhibited by the necessary restraint, to profound and prolonged loss of balance in nervous and psychic activity.

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