My general view is that best actor best suited to role should get the job. Obviously when it comes to colour and issues of ethnicity the choice is clear. But I do not believe you have to be transgender or have undergone sex reassignment surgery to be able play a character who has. Acting is acting after all.
Because I take very seriously the idea that I can make an impact in the world, I hold back my voice so I can make more of an impact when I do use it. A cause like One Billion Rising is something I want to scream about, and I want you to take that scream seriously because I don't fall out of nightclubs. I don't have photographers capture me spending untold amounts on a handbag.