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Two things significantly distinguish human beings from the other animals; an interest in the past and the possibility of language. Brought together they make a third: Art. The invisible city not calculated to exist. Beyond the lofty pretensions of the merely ceremonial, long after the dramatic connivings of plitical life, like it or not, it remains. Time past eternally present and undestroyed.

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Leon M. Lederman

When I talk about the pain and hardship of a scientist's life, I'm speaking of more than existential angst. Galileo's work was condemned by the Church; Madame Curie paid with her life, a victim of leukemia wrought by radiation poisoning. Too many of us develop cataracts. None of us gets enough sleep. Most of what we know about the universe we know thanks to a lot of guys (and ladies) who stayed up late at night.